A Review: Pharmacokinetics Application of Flouroquinolons

This review outlines some of pharmacokinetic parameters factors of fluoroquinolones antimicrobial agents. The oral absorption is not altered in human patients with disease. Plasma protein binding of the quinolones varies but newer quinolones less bound to plasma proteins. The serum concentration peak is reached rapidly. Most of the fluoroquinolone primary metabolites are active against bacteria: however, these metabolites have a shorter elimination half-life than their parent compound.